###### relative biological effectiveness

Scientific Experts, Publications, Genomes and Genes, Research Grants, Research Topics, Species about relative biological effectiveness

###### Range modulation in proton therapy planning: a simple method for mitigating effects of increased relative biological...

Proton beam therapy (PBT) has emerged as an important advance in radiation therapy, particularly for children and young adults. Although there are data supporting equivalent rates of cure using equivalent doses of proton versus photon treatments, the decreased dose to nearby OARs and substantial reduction of irradiated tissue volume is a promising strategy to address acute and late injury to normal tissues from therapy [1]. Additionally, a matched pair analysis [2] supports a range from no difference to fewer second malignancies in patients treated with protons versus photon therapy. Similar data comparing photon CSI to proton CSI from multiple institutions also suggests a clear correlation of irradiated volume to risk of second malignancy [3-6].. Increased tissue effects at the end of the spread out Bragg Peak (SOBP) is a defined, measured biologic phenomenon [7-10]. The potential for unintentional tissue injury due to putative increased

**relative biological effectiveness**(RBE) at the distal ...###### Radiation fields backscattered from material interfaces: I. Biological effectiveness<...

TY - JOUR. T1 - Radiation fields backscattered from material interfaces. T2 - I. Biological effectiveness. AU - Zellmer, D. L.. AU - Chapman, J. D.. AU - Stobbe, C. C.. AU - Xu, F.. AU - Das, I. J.. PY - 1998/10/1. Y1 - 1998/10/1. N2 - Confluent cultures of CHO-K1 and CHO-xrs5 cells were irradiated attached to 6 μm Mylar with 137Cs γ rays and 200 kVp X rays adjacent to scattering materials consisting of polystyrene, glass, aluminum, copper, tin and lead. The absorbed dose in cell nuclei was estimated from measurements of backscattered dose made with a parallel-plate ion chamber with a 5-μm Mylar window and a gas volume whose thickness was equivalent to -2.6 μm of cells or tissue. Cell inactivation after various doses was measured by clonogenic assays after trypsinization and enumeration. Survival curves constructed from data pooled from at least two independent experiments were best fitted to a linear-quadratic (LQ) or a linear equation for CHO-K1 and CHO-xrs5 cells, respectively. An average ...

###### JCI Insight - Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and...

Tumor radioresistance leading to local therapy failure remains a major obstacle for successful treatment of high-grade glioma. We hypothesized that distinct radiobiological features of particle therapy with carbon ions may circumvent glioma radioresistance. We demonstrate that carbon irradiation (CIR) efficiently eradicates radioresistant patient-derived glioma stem cells (GSCs), leading to growth inhibition and prolonged survival. The impact of CIR at the tumor-stroma interface was further investigated in 2 syngeneic mouse and 2 orthotopic GSC xenograft models. Intriguingly, tumor regressions and long-term local controls were observed at doses greater than or equal to 15-Gy CIR. Fractionated CIR further prolonged survival. The enhanced

**relative biological effectiveness**of CIR in vivo was attributed to its potent antiangiogenic effects and eradication of radioresistant hypoxic tumor cells. Blockade of the HIF1-α/stromal cell-derived factor 1/CXCR4 axis by CIR reduced the recruitment of ...###### Effects of the alpha-part… - Göteborgs universitet

BACKGROUND: The aim of this study was to investigate the biological effect of the alpha-particle-emitting isotope astatine-211 on the human cell line Colo-205 and to compare it with that of low-dose-rate gamma-radiation. MATERIALS AND METHODS: Plastic (PMMA) rotating phantoms were constructed, allowing precise dosimetry on a cellular level for both types of radiation. Growth assays using 96-well plates were used to estimate apparent cell survival for the two types of radiation. From this, the relative biological effect (RBE) could be estimated. RESULTS: Irradiation of the cells with 211At resulted in an RBE of 25.1 +/- 6.7 at 37% survival, and 17.3 +/- 2.5 at 10% survival, when compared with low-dose-rate gamma-irradiation. The absorbed dose at 37% survival, 0.12 Gy, corresponds to 2.2 traversals of alpha-particles through the cell nuclei. For cells irradiated with gamma-radiation (1 and 2 Gy), an apparent cell survival above unity was observed up to 50 hours post-irradiation, indicating a ...

###### JOPSS - Search Results

Sato, Tatsuhiko. Hoshasen Seibutsu Kenkyu, 48(2), p.137 - 146, 2013/06. Radiation doses are inhomogeneously distributed through microscopic sites such as DNA and cell nuclei. Although this inhomogeneity has been regarded as an important factor to determine the

**relative biological effectiveness**(RBE) over 50 years, it had not been frequently used in the quantitative analyses of radiation research because of the difficulty of evaluating the probability density function of dose in microscopic sites. We therefore developed a computational method for calculating the probability density functions in any radiation field and target size by means of combining a multi-scale particle transport simulation code with several mathematical models. Utilizing this method, we established a model for estimating cell-survival fractions in any radiation field. This model employs the probability density functions of domain and cell-nucleus doses as the indexes for characterizing the radiation fields.. ...###### Linear quadratic and exponential models, TANGOO.INFO

Linear quadratic and exponential models - Construct and compare linear, quadratic, and exponential models and solve problems. Construct linear and exponential functions, including arithmetic and ., wwe smackdown 8 14 18

###### Data Science - (Kalman Filtering|Linear quadratic estimation (LQE)) [Gerardnico]

Kalman Filtering or Linear quadratic estimation (LQE) is an algorithm that uses a series of measurements observed over time Because of the algorithms recursive nature, it can run in real time using only the present input measurements and the previously calculated state and its uncertainty matrix; no additional past information is required. ...

###### Design of a discrete Linear Quadratic Gaussian (DLQG) compensator for SSR damping using a sample invariant discrete model of...

The paper presents the design of a discrete linear quadratic gaussian (DLQG) compensator for SSR damping which includes a full order Kalman filter to estimate all the states of the system and a full state feedback regulator. The controller is tested on IEEE First Benchmark model for SSR studies. A discrete linear-time invariant (LTI) model of a thyristor-controlled series capacitor (TCSC) in the synchronously rotating DQ reference frame is used in this system in which, the sample invariance is achieved by a simple transformation of the zero sequence variables in the discrete domain. This model of discrete TCSC is then integrated with discretised LTI model of the rest of the system under study. Thyristor firing is based on current synchronised phase-locked loop and the sampling frequency is six times the synchronous frequency. The eigen value analysis is done for this integrated system for different angles of conduction of the thyristor. The modeled system is having 27 state variables including ...

###### Design of a discrete Linear Quadratic Gaussian (DLQG) compensator for SSR damping using a sample invariant discrete model of...

The paper presents the design of a discrete linear quadratic gaussian (DLQG) compensator for SSR damping which includes a full order Kalman filter to estim

###### CRAN Task View: Design of Experiments (DoE) & Analysis of Experimental Data

Computer experiments with quantitative factors require special types of experimental designs: it is often possible to include many different levels of the factors, and replication will usually not be beneficial. Also, the experimental region is often too large to assume that a linear or quadratic model adequately represents the phenomenon under investigation. Consequently, it is desirable to fill the experimental space with points as well as possible (space-filling designs) in such a way that each run provides additional information even if some factors turn out to be irrelevant. The lhs package provides latin hypercube designs for this purpose. Furthermore, the package provides ways to analyse such computer experiments with emphasis on what follow-up experiments to conduct. Another package with similar orientation is the DiceDesign package, which adds further ways to construct space-filling designs and some measures to assess the quality of designs for computer experiments. The package ...

###### CRAN Task View: Design of Experiments (DoE) & Analysis of Experimental Data

Computer experiments with quantitative factors require special types of experimental designs: it is often possible to include many different levels of the factors, and replication will usually not be beneficial. Also, the experimental region is often too large to assume that a linear or quadratic model adequately represents the phenomenon under investigation. Consequently, it is desirable to fill the experimental space with points as well as possible (space-filling designs) in such a way that each run provides additional information even if some factors turn out to be irrelevant. The lhs package provides latin hypercube designs for this purpose. Furthermore, the package provides ways to analyse such computer experiments with emphasis on what follow-up experiments to conduct. Another package with similar orientation is the DiceDesign package, which adds further ways to construct space-filling designs and some measures to assess the quality of designs for computer experiments. The package ...

###### CRAN Task View: Design of Experiments (DoE) & Analysis of Experimental Data

Computer experiments with quantitative factors require special types of experimental designs: it is often possible to include many different levels of the factors, and replication will usually not be beneficial. Also, the experimental region is often too large to assume that a linear or quadratic model adequately represents the phenomenon under investigation. Consequently, it is desirable to fill the experimental space with points as well as possible (space-filling designs) in such a way that each run provides additional information even if some factors turn out to be irrelevant. The lhs package provides latin hypercube designs for this purpose. Furthermore, the package provides ways to analyse such computer experiments with emphasis on what follow-up experiments to conduct. Another package with similar orientation is the DiceDesign package, which adds further ways to construct space-filling designs and some measures to assess the quality of designs for computer experiments. The package ...

###### Punctuation - AMA Manual of Style

Punctuation after a set-off equation is helpful and often clarifies the meaning. Display equations are often preceded by punctuation. In the linear quadratic equation model, the survival probability for cells receiving a j increment of radiation, Dj, is as follows: S = exp(−αDj − βDj), where α and β are the parameters of the linear quadratic equation model. Do not use periods after a set-off equation if the equation is preceded by a period. |

###### Punctuation - AMA Manual of Style

Punctuation after a set-off equation is helpful and often clarifies the meaning. Display equations are often preceded by punctuation. In the linear quadratic equation model, the survival probability for cells receiving a j increment of radiation, Dj, is as follows: S = exp(−αDj − βDj), where α and β are the parameters of the linear quadratic equation model. Do not use periods after a set-off equation if the equation is preceded by a period. |

###### Data Availability StatementThe data that support the results of this study are available from the corresponding author upon...

Data Availability StatementThe data that support the results of this study are available from the corresponding author upon reasonable request. useful biomarker for diagnosis and monitoring disease progression. Analyses of knockout mouse models have identified a functional role of extracellular S100A4 protein in fibrotic diseases, suggesting that suppressing its expression, release or function might be a promising therapeutic strategy. This review will focus on the role of extracellular S100A4 as a key regulator of pro\inflammatory signalling pathways and its relative biological processes involved in the pathogenesis of fibrosis. strong class=kwd-title Keywords: biomarker, damage\associated molecular pattern, extracellular S100A4, Fibrosis, inflammation 1.?INTRODUCTION An appropriate wound repair response is the premise of restoring the homeostasis of the damaged tissue. Wound maladaptation caused by chronic inflammation can result in fibrosis. 1 , 2 Fibrosis is the formation of excess fibrous ...

###### Fast neutron relative biological effectiveness determination via proton bombardment of V79 cells

M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission ...

###### Four-Dimensional Patient Dose Reconstruction for Scanned Ion Beam Therapy of Moving Liver Tumors (Journal Article) | SciTech...

Purpose: Estimation of the actual delivered 4-dimensional (4D) dose in treatments of patients with mobile hepatocellular cancer with scanned carbon ion beam therapy. Methods and Materials: Six patients were treated with 4 fractions to a total

**relative biological effectiveness**(RBE)-weighted dose of 40 Gy (RBE) using a single field. Respiratory motion was addressed by dedicated margins and abdominal compression (5 patients) or gating (1 patient). 4D treatment dose reconstructions based on the treatment records and the measured motion monitoring data were performed for the single-fraction dose and a total of 17 fractions. To assess the impact of uncertainties in the temporal correlation between motion trajectory and beam delivery sequence, 3 dose distributions for varying temporal correlation were calculated per fraction. For 3 patients, the total treatment dose was formed from the fractional distributions using all possible combinations. Clinical target volume (CTV) coverage was analyzed using ...###### Proton RBE for early intestinal tolerance in mice after fractionated irradiation

Background and purpose: To determine the influence of the number of fractions (or the dose per fraction) on the proton

**relative biological effectiveness**(RBE). Materials and methods: Intestinal crypt regeneration in mice was used as the biological endpoint. RBE was determined relative to cobalt-60 gamma rays for irradiations in one, three and ten fractions separated by a time interval of 3.5 h. Proton irradiations were performed at the middle of a 7-cm Spread Out Bragg Peak (SOBP). Results: Proton RBEs (and corresponding gamma dose per fraction) at the level of 20 regenerated crypts per circumference were found equal to 1.15 ± 0.04 (10.0 Gy), 1.15 ± 0.05 (4.8 Gy) and 1.14 ± 0.07 (1.7 Gy) for irradiations in one, three and ten fractions, respectively. Alpha/beta ratios as derived from direct analysis of the quantal radiation response data were found to be 7.6 Gy for gamma rays and 8.2 Gy for protons. Additional proton irradiations in ten fractions at the end of the SOBP were found to be more ...###### Monte Carlo simulation and analysis of proton energy-deposition patterns in the Bragg peak

The spatial pattern of energy depositions is crucial for understanding the mechanisms that modify the

**relative biological effectiveness**of different radiation qualities. In this paper, we present data on energy-deposition properties of mono-energetic protons (1-20 MeV) and their secondary electrons in liquid water. Proton-impact ionization was described by means of the Hansen-Kocbach-Stolterfoht doubly differential cross section (DDCS), thus modelling both the initial energy and angle of the emitted electron. Excitation by proton impact was included to account for the contribution of this interaction channel to the electronic stopping power of the projectile. Proton transport was implemented assuming track-segment conditions, whereas electrons were followed down to 50 eV by the Monte Carlo code PENELOPE. Electron intra-track energy-deposition properties, such as slowing-down and energy-imparted spectra of electrons, were calculated. Furthermore, the use of DDCSs enabled the scoring of electron ...###### Proton Irradiation Facility | TRIUMF : Canadas particle accelerator centre

The Proton Irradiation Facility (PIF) was designed primarily for single-event effect (SEE) studies and characterization of electronic components and detectors for the space environment. The energy spectrum of protons trapped in earth orbits peaks in the 10-100 MeV region (depending on the amount of intervening absorber) and drops by about an order of magnitude at 500 MeV. This makes the TRIUMF cyclotrons variable-energy capability of up to 500 MeV ideal for studies of space effects. Biological studies such as cell irradiations to measure the

**relative biological effectiveness**(RBE) of protons are also being carried out in conjunction with the Proton Therapy Centre.. PIF makes use of two different beam lines at TRIUMF for low-intensity radiation-damage studies. The lower energies, variable from as low as 5 MeV up to 120 MeV are available from the beam line BL2C, which is also used on a regular basis for proton treatments of ocular melanoma. Higher energies, from 120 MeV up to 500 MeV are ...###### Integrated network linear-quadratic model predictive control for disturbance on freeways | TU Delft Repositories

Faculty Civil Engineering and Geosciences. Department Transport & Planning. Date 2014-06-23. Abstract We propose an integrated approach for dynamic route guidance and ramp metering using Linear Quadratic Model Predictive Control (LQMPC). The main objective is to maximize the throughput of the network by guiding traffic flow towards to insufficiently utilized infrastructures. Due to the linear property of the LQMPC, it is fast enough for real-time online traffic control with a short control step (30 second for example). Simulation results from a case study demonstrate that the proposed traffic control approach has great potential to solve congestion when disturbances occur on freeways.. Subject freeway disturbance ...

###### New point system enhances prognosis for GIST patients

The scientists divided the GIST patients into four groups--extremely low risk, low risk, moderate risk, and high risk--on the basis of the size of the tumor and an index that calculates how many cells are dividing. Of the 170 patients with GIST tumors classified as extremely low risk, low risk, and moderate risk, only one patient had a tumor that could not be operated on, and three patients had recurrent tumors. This can be compared with the 89 patients with high-risk tumors, among whom 36 had inoperable tumors and 35 developed new tumors after surgery. Among patients with high-risk tumors, 63 percent died as a result of their GIST tumors, as did 83 percent of those who had tumors that had already spread extensively. On the other hand, only one percent of the patients died of GIST among those with extremely low, low, and moderate risk levels ...

###### Linear and quadratic relationships between retention and organic modifier content in eluent in Reversed Phase High-Performance...

TY - JOUR. T1 - Linear and quadratic relationships between retention and organic modifier content in eluent in Reversed Phase High-Performance Liquid Chromatography: A systematic comparative statistical study. AU - Baczek, T.. AU - Markuszewski, M.. AU - Kaliszan, R.. AU - Straten, van, M.A.. AU - Claessens, H.A.. PY - 2000. Y1 - 2000. N2 - Statistical evaluation of linear and quadratic models of chromatographic retention was performed. The relationships describing retention were derived for a set of 23 carefully selected test analytes chromatographed on 18 HPLC columns using methanol-water or acetonitrile- water solutions as mobile phase. It was ascertained whether the square term in the quadratic model improves the description of chromatographic retention in a statistically significant manner. It was also checked whether the retention data extrapolated to a hypothetical neat water eluent (log kw) obtained with the two models and the two organic modifiers are equivalent or should be considered ...

###### The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture...

Sigma-Aldrich offers abstracts and full-text articles by [Shin-Ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Keizo Tano, Minoru Suzuki, Natsuko Kondo, Masaru Narabayashi, Yosuke Nakagawa, Tsubasa Watanabe, Akira Maruhashi, Koji Ono].

###### Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes - Tabular View -...

This study will evaluate the biological effectiveness and safety of the HerpV vaccine in combination with adjuvant QS-21. The Safety and tolerability of HerpV plus QS-21 will also be evaluated by collecting number and severity of adverse events throughout the study.. Biological effectiveness will be evaluated by comparing the viral shedding rate during the treatment period as compared to the baseline period of the study.. Subjects will undergo a baseline/ screening period. This is a 45 day period when the subject collects a swab of the genital area each day. . In case of a recurrence, subjects will be required to collect two swabs a day. If the subject collects at least 80% of the swabbing samples and meets all eligibility criteria they may enroll in the study.. Subjects who meet all inclusion and no exclusion criteria will be enrolled and randomized in Study Period 1 (treatment period). In order to assure the trial enrolls a good representation of women and men, a prespecified cap on women will ...

###### Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research. - 指紋 - 臺北醫學大學

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###### 350 km from Fukushima: I get very sick when there for 3-4 months - Had to leave after bleeding form nose - Theres a health...

Thanks WL…every resource is welcome. That is an excellent list of places in Japan suffering severe nuclear fallout.. Its helpful to keep in mind two modern radiation units are grays and Sieverts as opposed to some of the archaic units. Here is a brief but excellent description of how they complement the quest to measure radiation from nuclear sources:. Gray. The IS unit for the energy absorbed from ionizing radiation, equal to one joule per kilogram. An absorbed dose of one gray is equal to the absorption of one joule of radiation energy by one kilogram of matter.. The gray is the correct unit to use when you wish to monitor energy absorbed per unit mass.. Sievert. The IS unit for the amount of ionizing radiation required to produce the same biological effect as one rad of high-penetration x-rays, equivalent to a gray for x-rays. It measures the radioactive dose equivalent. One sievert is equal to one gray multiplied by a relative biological effective factor, Q, and a factor that takes into ...

###### Quantification of age-related shape change of the human rib cage through geometric morphometrics

The aim of this study is to quantify patterns of age-related shape change in the human thorax using Procrustes superimposition. Landmarks (n=106) selected from anonymized computed tomography (CT) scans of 63 adult males free of skeletal pathology were used to describe the form of the rib cage. Multivariate linear regression was used to determine a relationship between landmark location and age. Linear and quadratic models were also investigated. A permutation test employing 1×105 random trials was used to assess the model significance for both model formulations. Linear relationships between the centroid size (CS) of a landmark set and the corresponding individuals height, weight, and BMI were conducted to enable scaling of the dimensionless results from the Procrustes analysis. A significance level of α=0.05 was used for all tests. The average age of the study subjects was 57.0±17.3 years. Complete landmark sets were obtained from most of the scans (44 of 63). The quadratic relationship ...

###### Fondation Recherches 3R / Projets / 3R-Project 89-03

Adverse health effects by inhaled and deposited particles are of great concern. In addition, therapeutic aerosols become increasingly important for the treatment of lung and other diseases. The interaction of particles with the inner surface of the lungs is fundamental for their biological effectiveness in the organism, though poorly understood and precluded from being studied in humans. A large number of animals are used to test the effects of aerosol particles on a living system by whole-body or nose-only exposures. Such experiments are time consuming and they are stressful for the animals. Furthermore, the increase of knowledge in the use of animal models is hampered for various reasons, such as the long time lapse between aerosol application and lung fixation, the lack of methods for direct studies, or artefacts produced by chemical lung fixation. Cell cultures which are in common use today are deficient in important structural components of the inner lung surface, such as macrophages, ...

###### Biological Dosimetry Network in Africa: Establishment of a Dose-Response Curve Using Telomere and Centromere Staining. |...

MetaSystems products have been featured in many publications. This page lists only a few. Use the filter tools to find publications that match your interest.

###### Linear quadratic and exponential models worksheet pdf

UNIT 5: COMPARING AND CONTRASTING FUNCTIONS In this unit, students compare and contrast linear, quadratic, and exponential functions. They distinguish between situations that can be modeled by each type of function. They will build new functions from existing functions and interpret functions for specific situations. Construct and Compare Linear, Quadratic, and Exponential Models and Solve

###### Risk-adaptive security isnt fancy jargon, says Forcepoints Praveen Asthana | IDG Connect

Forcepoint CMO Praveen Asthana talks about why there is no silver bullet to beat bad guys, how CISOs can have a fool-proof IT infrastructure, and the new marketing mantras for security companies.

###### Terrestrial, Atmospheric and Oceanic Sciences (TAO) - A Case Study of Energy Deposition and Absorption by Magnetic Cloud...

Several possible characteristics of magnetic clouds (MCs) have been discussed in the literature, but none appears to explain all the effects from accu...

###### Cells | Free Full-Text | Mechanistic Modeling of the Relative Biological Effectiveness of Boron Neutron Capture Therapy | HTML

Accurate dosimetry and determination of the biological effectiveness of boron neutron capture therapy (BNCT) is challenging because of the mix of different types and energies of radiation at the cellular and subcellular levels. In this paper, we present a computational, multiscale system of models to better assess the

**relative biological effectiveness**(RBE) and compound biological effectiveness (CBE) of several neutron sources as applied to BNCT using boronophenylalanine (BPA) and a potential monoclonal antibody (mAb) that targets HER-2-positive cells with Trastuzumab. The multiscale model is tested against published in vitro and in vivo measurements of cell survival with and without boron. The combined dosimetric and radiobiological model includes an analytical formulation that accounts for the type of neutron source, the tissue- or cancer-specific dose–response characteristics, and the microdistribution of boron. Tests of the model against results from published experiments with and without###### Dose-Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy (Journal...

Purpose: We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials: This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (

**relative biological effectiveness**[RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose-volume parameters associated with radiation necrosis. Results: Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who ...###### Development of sensitive EPR dosimetry methods

Electron paramagnetic resonance (EPR) dosimetry using the well established dosimeter material alanine is a generally accepted dosimetric method for measurements of high absorbed doses. Alanine EPR dosimetry is however not sensitive enough for high precision measurements of low (, 5 Gy) absorbed doses using reasonably measurement times and small dosimeters. It has therefore not been possible to fully exploit the benefits of EPR dosimetry for applications in radiation therapy.. The aim of this thesis was to show that sensitive EPR dosimetry is a competitive method for applications in radiation therapy fulfilling the requirements of measurement precision. Our strategy for reaching this goal was to search for new, more sensitive, EPR dosimeter materials fulfilling the criteria of being tissue equivalent, having a high radical yield and having a narrow EPR spectrum suitable for dosimetry. The best materials were found among formates and dithionates. Doping with small amounts of metal ions and ...

###### Details and Download Full Text PDF: Four-dimensional treatment planning in layer-stacking boost irradiation for carbon-ion...

Materials And Methods: A total of 21 patients who were treated with conventional passive carbon-ion beam for pancreatic cancer underwent 4DCT imaging under free-breathing conditions. We defined two types of clinical target volume (CTV) for the initial and boost irradiations: CTV1 included the gross tumor volume (GTV) and peripheral organs, and CTV2 included the GTV only with an added uniform 2-mm margin. Planning target volumes 1 and 2 (PTV1 and PTV2) were calculated by adding the range variation considered internal margin defined by 4DCT to the respective CTVs. The initial prescribed dose (=45.6Gy (RBE); RBE-weighted absorbed dose) was given to PTV1, and the boost dose was increased up to 26.4Gy (RBE) and given to PTV2. Dose assessments were compared between irradiation techniques using the paired t-test ...

###### PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models. |...

Although cancer is the leading cause of disease-related mortality in children, the relative rarity of pediatric cancers poses a significant challenge for developing novel therapeutics to further improve prognosis. Patient-derived xenograft (PDX) models, which are usually developed from high-risk tumors, are a useful platform to study molecular driver events, identify biomarkers and prioritize therapeutic agents. Here, we develop PDX for Childhood Cancer Therapeutics (PCAT), a new integrated portal for pediatric cancer PDX models. Distinct from previously reported PDX portals, PCAT is focused on pediatric cancer models and provides intuitive interfaces for querying and data mining. The current release comprises 324 models and their associated clinical and genomic data, including gene expression, mutation and copy number alteration. Importantly, PCAT curates preclinical testing results for 68 models and 79 therapeutic agents manually collected from individual agent testing studies published since ...

###### What if that regression-discontinuity paper had only reported local linear model results, and with no graph? « Statistical...

The commenter made the seemingly reasonable point that, since the authors actually did use the model that Guido and I recommended, and it gave the same results as what they found under the controversial model, what was my problem?. What if?. To put it another way, what if the authors had done the exact same analyses but reported them differently, as follows:. - Instead of presenting the piecewise quadratic model as the main result and the local linear model as a side study, they couldve reversed the order and presented the local linear model as their main result.. - Instead of graphing the fitted discontinuity curve, which looks so bad (see graphs above), they couldve just presented their fitted model in tabular form. After all, if the method is solid, who needs the graph?. Heres my reply.. First, I do think the local linear model is a better choice in this example than the global piecewise quadratic. There are cases where a global model makes a lot of sense (for example in pre/post-test ...

###### CRAN - Package LEAP

Advances in sequencing technology now allow researchers to capture the expression profiles of individual cells. Several algorithms have been developed to attempt to account for these effects by determining a cells so-called pseudotime, or relative biological state of transition. By applying these algorithms to single-cell sequencing data, we can sort cells into their pseudotemporal ordering based on gene expression. LEAP (Lag-based Expression Association for Pseudotime-series) then applies a time-series inspired lag-based correlation analysis to reveal linearly dependent genetic associations.. ...

###### Browsing by Author Puig P

The goal in biological dosimetry is to estimate the dose of radiation that a suspected irradiated individual has received. For that, the analysis of aberrations (most commonly dicentric chromosome aberrations) in scored ...

###### IEEE - Institute of Electrical and Electronics Engineers, Inc. - Control of voltage source converters with LCL filter using...

The aim of this paper is to propose and compare two multivariable current controllers of voltage source converters (VSCs) connected to the grid through an LCL filter. The first proposal is a linear quadratic (LQ) servocontroller,

###### Tokushima University / Educator and Researcher Directory --- Electrical and Electronic Engineering

状態に遅れ型むだ時間を含む系·状態に中立型むだ時間を含む系·入力にむだ時間を含む系におけるメモリーレスフィードバックによる最適レギュレータの構成法に関する研究, 集中定数部分と分布定数部分が結合した構造をもつ系における集中定数部分制御による最適レギュレータの構成法に関する研究 (linear system, control theory, systems with time-delay, distributed parameter systems, Linear Quadratic Regulator, pole assignment ...

###### Radiobiology Equipment Arrives :: College of Saint Rose, The

Scanned on 02/02/2009 using an Epson 20000 scanner at 300 dpi and saved as a .tif for archival purposes. Modified to 150 dpi and saved as a .jpg for web access ...

###### Radiobiology Unit | Państwowy Zakład Higieny

Head of Department Associate Professor Małgorzata Dobrzyńska, PhD, DSc Employees Mgr Aneta Gajowik Tech. Izabela Remiszewska Description Estimation of mutagenic effects of exposure to X-rays and chemicals alone or in combination induced in somatic and germ cells of mice in in vivo studies. micronuleus test in

###### p-Aminobenzamidine-Matrix

By kind personal communication of Dr DEBY-DUPONT, Laboratory of Biochemistry and Radiobiology - University of Li ge (Belgium).. Important note: All operations were carried out at 0 C-4 C ...

###### You searched for COPD | Lets Talk Respiratory - Lets Talk Respiratory

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###### Do You Have a Stressed Dog? Lets Talk Stress in Dogs

Is your dog stressed out? How can you identify stress in dogs and what can be done to help a stressed dog? Lets examine some options right here.

###### I Let Gwen Stacy Die - TV Tropes

The I Let Gwen Stacy Die trope as used in popular culture. Often, a hero needs more of a reason to keep on fighting than just to save the day. He needs to …

###### Daresbury Commercial Properties to Let - Primelocation

Find a wide range of commercial properties to let in Daresbury. Our great selection includes properties to rent from all leading Daresbury estate agents.

###### A l gszennyezetts g halvasz let st okozhat

Van sszef gg s a leveg szennyezetts ge s a halvasz let s k z tt, ll tja egy friss kutat s, amelyet a finn Oului Egyetem munkat rsai v geztek.

###### What Are Ethnobotanicals? Key Facts, Types & Importance

Lets have a look in detail as to what ethnobotanicals are and why people use them. Know the key facts, types and effects of ethnobotanicals.

###### April 2018 - umagento

Whether youre looking for answers, would like to solve a problem, or just want to let us know how we did, youll find many ways to contact us right here. Do not hesitate to give us a call if you need another information.. ...

###### Can you get pregnant from pre-ejaculatory fluid?

Before we get on to the answer, lets first understand what pre-ejaculatory fluid is and what its function is. What is pre-ejaculatory...

###### BRMO presentatie (groot) - RIVM

BRMO presentatie - groot (Let op: 38 megabytes). Gebruik de onderstaande link om het document te downloaden.. BRMO-groot 14 februari 2016, PPTX , 37MB ...